R in Resolver One (and perhaps IronPython generally)
We've just announced the winner of this month's round of our competition at Resolver Systems, and it's a great one; Marjan Ghahremani, a student at UC Davis, managed to work out how you can call R (a powerful statistical analysis language) from our spreadsheet product Resolver One. You can download a ZIP file with a detailed PDF describing how it works and a bunch of examples.
If you're not interested in Resolver One, but want to use R from your own IronPython scripts, you may be able to do that too, using her instructions as guidelines -- I've not tried it myself, but there are no obvious blockers. If you do try it out, I'd love to hear how it goes.